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First published online July 12, 2005

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RNA gets structural

The localization of RNAs to specific areas within cells or embryos is essential for many aspects of development. Generally, RNA localization acts by facilitating localized protein production. However, Kloc and co-workers now report that both coding and non-coding RNAs help to organize the cytoskeleton in the vegetal cortex of Xenopus oocytes (see p. 3445). By using antisense oligonucleotides to deplete oocytes of VegT mRNA or non-coding Xlsirts RNA, the researchers show that the destruction of these RNAs, which normally localize to the vegetal cortex, disrupts the cytokeratin (but not the actin) cytoskeleton at the vegetal cortex in a transcript-specific manner, and interferes with germinal granule structure and with primordial germ cell formation. The researchers also show that VegT and Xlsirts RNAs integrate into the cytokeratin cytoskeleton in Xenopus oocytes, and suggest that RNAs may play similar structural roles in other cell types and organisms.

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Related articles in Development:

Potential structural role of non-coding and coding RNAs in the organization of the cytoskeleton at the vegetal cortex of Xenopus oocytes

Malgorzata Kloc, Katarzyna Wilk, Diana Vargas, Yuri Shirato, Szczepan Bilinski, and Laurence D. Etkin
Development 2005 132: 3445-3457. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?