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First published online July 12, 2005

Development 132, 1505e (2005)
© The Company of Biologists Limited
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In this issue

The Yin and Yan of border cell migration


Invasive cell migration – a feature of both normal development and metastatic cancer – is regulated by numerous signalling pathways, transcription factors and cell-adhesion molecules, the coordination of which is poorly understood. Now, on p. 3493, Schober and colleagues report that the ETS transcription factor Yan is a key regulator of the stereotypic migration of border cells during Drosophila oogenesis. The researchers show that Yan is dynamically expressed and regulated by the Notch, JAK/STAT and RTK signalling pathways in border cells during their migration, and that increased or decreased Yan activity delays their migration by affecting the turnover of the cell-cell adhesion molecule E-cadherin. ETS transcription factors are often upregulated in invasive tumours, note the researchers, so these results provide important mechanistic insights not only into the control of developmental invasive cell migration but possibly also into pathological cell migration.


Related articles in Development:

Function of the ETS transcription factor Yan in border cell migration
Markus Schober, Ilaria Rebay, and Norbert Perrimon
Development 2005 132: 3493-3504. [Abstract] [Full Text]  




This Article
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