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Fig. 4. The hypoxia-normoxia transition promotes spongiotrophoblast expansion. Hypoxia fails to redirect wild-type or mutant TS cell fate in vitro. In contrast, hypoxia followed by reoxygenation (2*) led to an expansion of the spongiotrophoblast lineage, as shown by the dramatic enhancement of 4311 expression in wild-type TS cells.





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