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Fig. 5. HDAC activity is altered in Arnt-null TS cells. (A)
Differentiation of wild-type TS cells was associated with increased levels of
acetylated H4 (Ac-H4). A similar increase was observed during differentiation
of the Arnt-null TS cells, although baseline levels in the
undifferentiated state were much higher than those observed in wild-type
cells. HDAC1 expression, which does not change during differentiation, was
used as a loading control. (B) Compensatory upregulation of multiple HDACs was
observed in whole-cell lysates prepared from undifferentiated
Arnt-null TS cells. (C) Analysis of nuclear extracts revealed altered
translocation of multiple HDACs in mutant TS cells.
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