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Fig. 5. The Gata4 lateral mesoderm enhancer contains three conserved, candidate FOX-binding sites, two conserved, candidate SMAD-binding sites, and three perfectly conserved, candidate GATA factor binding sites. ClustalW analysis comparing the sequence of the conserved enhancer region from mouse, human and opossum, identified: three conserved candidate binding sites for FOX transcription factors (blue boxes), denoted as Fox I, Fox II and Fox III; two conserved, candidate binding sites for SMAD transcription factors (yellow boxes), denoted as Smad I and Smad II; and three perfectly conserved, candidate binding sites for GATA factors (red boxes), denoted as gata I, gata II and gata III. Asterisks denote nucleotides that have been perfectly conserved among all three species.





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