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Fig. 1. Pleiotropic Notch defects in Mib1–/–
embryos. (A,B) Wild-type (A) and Mib1–/– (B)
embryos at E9.0. The wild-type embryo has the first and second branchial
arches (A, arrows), while the Mib1–/– embryo
only has the first branchial arch (B, arrow) with a distended pericardial sac
(asterisk) and small, irregular somites (arrowheads). (C-F) Vascular defects
in the yolk sac of E9.5 Mib1–/– embryos (D,F),
as compared with the wild type (C,E). The blood vessels are indicated
(asterisks). (G,H) Transverse sections of wild-type (G) and
Mib1–/– (H) embryos at E9.5. The
Mib1–/– embryo has a smaller dorsal aorta (da;
inset i), a thinner neural tube (nt), loss of mesenchymal cells (asterisk), an
enlarged pericardial cavity (#) and a fused notochord (inset ii). (I,J)
Transverse section of wild-type (I) and coronal section of
Mib1–/– (J) embryos at E9.5. A kinked neural
tube (asterisk) and irregular somites (arrows) are evident in the
Mib1–/– embryo (K) Myogenin expression
(bracket) in E9.5 wild-type (left) and Mib1–/–
(right) embryos. (L-P) Expression of Uncx4.1 (L), Dll1 (M),
Hes7 (N), lunatic fringe (Lfng) (O) and Heyl (P) in
E8.5 wild-type (left) and Mib1–/– (right)
embryos. The Mib1–/– embryos lack the
characteristic expression of Uncx4.1 (L, arrows), Dll1 (M,
arrows and inset), Hes7 (M, arrow and bracket), Lfng (O,
arrow and bracket) and Heyl (P, arrow and inset).
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