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Fig. 1. FBF and FOG-1 control larval germline proliferation. (A-C,F) DAPI-stained germlines. Broken lines indicate germlines; small arrowheads indicate sperm; large arrowheads indicate oocytes or oocyte-like cells; arrow in A-E indicates distal end; vul, vulva. fog-1, fog-1(q250). (A) fog-1 homozygote. Size of adult germline is normal, but only oocytes are made (Barton and Kimble, 1990). (B) fbf-1 fbf-2 adult. Germline is reduced to ~60 germ cells/arm with only sperm (Crittenden et al., 2002). (C) fog-1; fbf-1 fbf-2 triple mutant. Germline is reduced to ~10 germ cells (white arrowheads) and no sperm are made. (D) fog-1; fbf-1 fbf-2 triple mutant, stained with antibodies to the germ cell marker PGL-1; few germ cells are present (white arrowheads). (E) fog-1; fbf-1 fbf-2 Nomarski micrograph; few germ cells are present (white arrowheads). (F) L2 fog-1; fbf-1 fbf-2. Arrow indicates crescent-shaped nucleus typical of early meiosis. Scale bars: 10 µm. (G) Larval germline proliferation. eL1, early L1; lL1, late L1. n≥4 at all stages.





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