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Fig. 2. Gross bony structures and histology of P1 Fgfr2+/S252W
mice. (A,C,E,G,I,K,M,O,Q,S) Control littermates; (B,D,F,H,J,L,N,P,R,T)
corresponding regions in mutant mice. (A-H) Alizarin Red S and Alcian Blue
staining of (A-F) the skull and (G,H) the chest. (I-R) HE staining of the
(I,J) brain, (K,L) palate, (M,N) trachea, (O,P) lung, and (Q,R) growth plates
of long bone. (S,T) TRAP staining for growth plates. The mutant mice have: a
wide interfrontal suture (B, arrows define the width of the suture); a
shortened nasal snout (D, arrow); fusion of the joints between the zygomatic
arch bones (F, arrows); a sternum with abnormal fusions and bifid xiphoid
process (H, arrow); hydrocephalus with enlarged ventricles (J, arrows); a
palate defect (L, arrow); a complete cartilage sleeve of the trachea with
abnormal cartilage thickening (N); atelectasis of the lungs with alveolar
proteinaceous fluid (P); chondrocyte hypertrophy and disorganization with
irregular and thickened ossifying cartilaginous spicules in the growth plates
of long bone (R); and decreased osteoclasts at the chondro-osseous junction
(T; S, arrow shows normal osteoclasts stained red). LV, lateral ventricle; 3V,
third ventricle; TC, tracheal cartilage; P, zone of chondrocyte proliferation;
H, zone of hypertrophy; M, zone of mineralization; O, zone of ossification at
the chondro-osseous junction. Scale bars: A-H, 1 mm; I-T, 50 µm.
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