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Fig. 3. Skeletal features of hypomorphic Fgfr2+/S252Wflox/S252W mice. (A) The gross appearance shows the smaller body size of the mutant mouse at 8 weeks of age. (B) X-ray of the whole body at 8 weeks of age shows short nasal bones and maxillary bones with overriding lower incisors. (C) Micro-CT of the skull of a 10-month-old Fgfr2+/S252Wflox/S252W mouse (right) shows extreme brachycephaly, diminutive and curved nasal bones, extreme reduction anteroposteriorly of the frontal bones, obliterated fronto-nasal, fronto-premaxillary and maxillary-premaxillary sutures, and a defect of the interfrontal suture in the skull (arrow).





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