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First published online August 2, 2005

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Cell cycling through development

Cell-cycle progression is precisely regulated during development by cell-cycle regulators that act at important developmental transitions. On p. 3669, Swan and colleagues now report that the Drosophila Cks gene, Cks30A, interacts with Cdk1 to regulate progression through female meiosis and the mitotic divisions of the early embryo. Cks is a highly conserved protein that nevertheless has distinct cell-cycle roles in different organisms. The researchers report that Cks30A corresponds to the Drosophila maternal effect lethal gene remnants. Through phenotypic analysis of mutant alleles of Cdk30A, they show that Cks30A is crucial for Cdk1 activity in spindle assembly and anaphase progression during female meiosis and early embryonic mitosis. Finally, the authors provide novel mechanistic insights into how Cks30A controls these specialised cell cycles by showing that the Cks30A-Cdk1 complex regulates Cyclin A levels, possibly through the activity of the female germline-specific anaphase-promoting complex adaptor Cortex.

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Related articles in Development:

Drosophila Cks30A interacts with Cdk1 to target Cyclin A for destruction in the female germline

Andrew Swan, Gail Barcelo, and Trudi Schüpbach
Development 2005 132: 3669-3678. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?