QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online August 2, 2005

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Motor driven cytoplasmic streaming

In large cells, cytoplasmic streaming evenly disperses some cellular components and may help to concentrate others at specific locations. In Drosophila oocytes, slow streaming occurs during the localisation of pattern formation determinants; fast streaming cuts in later to evenly mix the yolk. On p. 3743, Serbus and colleagues report that while all cytoplasmic streaming in Drosophila oocytes requires the plus-end-directed microtubule motor kinesin-1, dynein (a minus-end-directed motor) and the actin cytoskeleton impede kinesin's fast-streaming activity. The researchers use time-lapse microscopy, suppression of dynein activity, and analysis of kinesin heavy chain mutations to propose a model in which a novel competition between dynein and kinesin initially prevents the parallel ordering of microtubules, allowing only short-range currents. The release of a dynein inhibitor subsequently allows the establishment of a self-amplifying loop of plus-end-directed organelle motion and parallel microtubule orientation, which drives fast streaming.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Dynein and the actin cytoskeleton control kinesin-driven cytoplasmic streaming in Drosophila oocytes

Laura R. Serbus, Byeong-Jik Cha, William E. Theurkauf, and William M. Saxton
Development 2005 132: 3743-3752. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?