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First published online August 2, 2005

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Transdetermination: resetting chromatin

During development, cells become determined or fixed in particular developmental pathways. However, each primordium contains a few cells that can be stimulated to change their fate. For example, in Drosophila, ectopic Wingless expression induces specific leg imaginal disc cells to transdetermine into wing cells. Klebes and co-workers investigate how this example of cellular plasticity is regulated by examining gene expression patterns in transdetermining cells and non-transdetermining cells from the same disc (see p. 3753). Genes implicated in transdetermination by this analysis include lamina ancestor (lama) and the Polycomb and trithorax group of chromatin regulators; functional assays provide additional evidence for the involvement of these genes in transdetermination. The researchers conclude that transdetermination depends on resetting the chromatin structure, which is only possible in a few cells. These insights into developmental plasticity may advance the development of human stem cells for medical applications.

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Related articles in Development:

Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genes

Ansgar Klebes, Anne Sustar, Katherina Kechris, Hao Li, Gerold Schubiger, and Thomas B. Kornberg
Development 2005 132: 3753-3765. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?