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Fig. 1. Domain structure of proteins showing similarity to FY. BLAST searches
identified eukaryotic proteins with amino acid similarity to FY (Altschul et
al., 1990). The conserved WD repeats are shared between each of the proteins
and are shown in blue. The divergent C-terminal domains are shown in grey with
the presence of PPLPP motifs or collagen-like domains indicated. These
C-terminal domains show little similarity between proteins, apart from the
highlighted motifs. The sequences represented are: Saccharomyces
cerevisae ScPfs2 (NP_014082), Schizosaccharomyces pombe SpPfs2
(S62544), Neurospora crassa NcPfs2 (XP_322123), Arabidopsis
thaliana AtFY (NP_196852), Oryza sativa OsFY (BAB86205,
Drosophila melanogaster DmPfs2 (NP_730982), Caenorhabditis
elegans CePfs2 (NP_496985), Homo sapiens HsWDC146 (NP_060853.2),
Mus musculus (BAC00776 and Tetraodon nigroviridis TnWDC146
(CAD27805.
