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Fig. 1. Localisation of NrCAM on RGCs. (A,B) Double labelling of a retina section stained by (A) NrCAM serum and (B) the nuclear marker DAPI. In the E6 retina, NrCAM is exclusively present in the optic fibre layer (OFL) and the optic nerve (ON), both formed by RGC axons. The ganglion cell layer (GCL), containing the RGC somata, is clearly NrCAM negative. The as yet undifferentiated neuroepithelial cells (NEC) are almost entirely NrCAM negative, with only a minor staining in the ventricular region near the pigment epithelium. (C) Single-cell cultures stained for NrCAM show that NrCAM is present on the entire RGC axon and is highly concentrated in its distal region. (D) NrCAM is strongly present in the central part of the RGC growth cone, and to a lesser degree on the lamellipodia and filopodia. Scale bars: (A,B) 100 µm; (C) 50 µm; (D) 10 µm.





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