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Fig. 7. Model for the function of SAX-3 in C. elegans embryonic
development. During embryonic development most cells reach their final
position through a combination of local divisions and directed movements.
SAX-3/VAB-1 pathways are required for neuroblast movements that result in the
closing of the gastrulation cleft. SAX-3/VAB-1 may also be required to
position early AB epidermal precursors that will generate the future epidermal
seam cells and ventral epidermal cells. Our results are consistent with SAX-3
functioning with VAB-1 in parallel pathways or perhaps through a receptor
complex (SAX-3/VAB-1). At the same time SAX-3 functions independently of VAB-1
for epidermal morphogenesis; for example, during the migration of dorsal
epidermal cells.
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