spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 7. Effects of Smed-netrin1 and netrin2 RNAi in the regeneration and maintenance of the planarian CNS. (A-B) Normal cephalic ganglia (A) and VNCs (B) regenerate after Smed-netrin1 RNAi. Arrowhead points to the commissure connecting the cephalic ganglia. (C-D) After Smed-netrin2 RNAi the anterior commissure is thickened (arrowhead in C) and the ganglia are wider than normal. The VNCs regenerate in a disorganized meshwork of projections (D). (E) Posterior uninjured region of an anterior regenerating animal showing ectopic processes (arrowhead) between the VNCs after Smed-netrin2 RNAi. (F) Newly regenerated tail region showing abnormal regeneration of the VNCs after Smed-netrin2 RNAi. All regenerants were fixed 2 weeks after amputation. (G-H) Disorganized neural pattern with ectopic axonal processes in the cephalic (G) and post-pharyngeal (H) regions of intact planarians 2 weeks after Smed-netrin2 RNAi. B,D,E,G and H are single confocal planes; A shows confocal projections through 5.6 µm; C,F show confocal projections through 4.8 µm. (A-D,F-H) Anterior to the left. (E) Anterior to the top. Scale bar: 100 µm. cg, cephalic ganglia.





Right arrow Return to article