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First published online August 11, 2005

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Notched boundary fences

Many tissues are subdivided during development into compartments by boundaries that prevent the free mixing of cells. The cellular mechanisms underlying compartmentalization, although poorly understood, are widely thought to involve compartment-specific cell affinities. On p. 3823, Major and Irvine propose a different model for the dorsoventral compartmentalization of the Drosophila wing in which Notch activation creates a `fence' between the compartments. The researchers show that a stripe of Notch activation is sufficient to create a sharp separation between cell populations, irrespective of their dorsal or ventral identities. The cells at the DV boundary have a characteristic shape, and F-actin accumulates in these cells at the adherens junctions at this interface. Notch activation is both necessary and sufficient for these phenotypes, report the researchers, who conclude that Notch regulates DV compartmentalization by modulating the organization of the actin cytoskeleton to create a boundary fence.

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Related articles in Development:

Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing

Robert J. Major and Kenneth D. Irvine
Development 2005 132: 3823-3833. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?