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Fig. 8. grh mutant neuroblasts are insensitive to AbdA-induced apoptosis. (A-D) Abdominal region of balanced control (A), hs-abdA (B) and grh370, hs-abdA (C) larvae that received a heat shock at 48 hours and were labelled for Mira and AbdA at 72 hours. Ectopic AbdA expression from the hs-abdA transgene persists for at least 24 hours after heat shock and is observed posterior to the endogenous AbdA domain. The exogenous AbdA activity is sufficient to eliminate all Mira-positive neuroblasts from the abdomen of hs-abdA but not grh370, hs-abdA larvae. (D) A single confocal section of a grh370, hs-abdA larva showing three central abdominal neuroblasts that have expressed AbdA for 24 hours after heat-shock induction but have remained resistant to apoptosis.





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