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Fig. 6. Nephrogenic progenitors are preferentially lost in T-Cre; Fgf8Flox/{Delta}2,3 kidneys. (A,B,E,F) E14.5 kidneys; (C,D,G,H) E16.5 kidneys. (A-D) Sustained expression of the stromal marker Foxd1/BF2 in sections from whole-mount ISH of control (A,C) and T-Cre; Fgf8Flox/{Delta}2,3 (B,D) metanephroi. (E-H) Depletion of the cap cell marker Cited1 demonstrated by immunohistochemistry of control (E,G; arrowheads indicate cap formation) and T-Cre; Fgf8Flox /{Delta}2,3 (F,H) metanephroi.





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