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Fig. 10. Rescue of brain vascular abnormalities in embryos with the nestin-Psen1
transgene on the Psen1–/– background. (A-C)
Staining with isolectin B4 was performed on paraffin-embedded E12.5 embryos
from wild-type (A) and Psen1–/– (B) embryos,
and embryos with the nestin-Psen1 transgene on the
Psen1–/– background (C). Sections through the
lateral telencephalon are shown. Vessels in the
Psen1–/– embryo are enlarged. (D-L) Isolectin
staining (E,H,K) was combined with nestin immunostaining (D,G,J) on
paraffin-embedded E18.5 embryos from wild-type (D-F) and
Psen1–/– (G-I) embryos, and embryos with the
nestin-Psen1 transgene on the Psen1–/–
background (J-L). Merged images are shown in F,I,L. Regions along the cortical
surface of the lateral telencephalon are illustrated. The lectin-stained
vessels in the Psen1–/– brain are distorted
and lobular appearance, and this pattern is normalized by the nestin-Psen1
transgene. The pattern of nestin staining is altered in the
Psen1–/– embryo. Scale bar: 100 µm for A-C;
50 µm for D-L.
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