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Fig. 7. A model for the sequential action of Wnts on somite epithelialisation and
compartimentalisation. (A) The Wnt6 signal, secreted by the ectoderm, binds to
Fz7 receptor expressed by the cells of the segmental plate. (B) This
interaction activates the canonical, ß-catenin pathway that controls the
expression of paraxis and maintains the epithelial structure of the
dorsal part of the somite, while the ventral region disaggregates to form the
sclerotome. (C) Cells in the medial-most region of the dermomyotome receive a
Wnt1 signal from the dorsal neural tube, which activates Fz2 receptor and
induces Wnt11 expression in this region, thus defining the
dorsomedial compartment of the dermomyotome.
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