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Fig. 4. Candidate protomap genes are up- and downregulated in Fgfr1 mutant
cortices in a manner consistent with their predicted regulation. (A) Cluster
of genes up- and downregulated in the conditional Fgfr1 mutant dorsal
telencephalon at E12.5. Nine independent comparisons of gene expression
between single homozygous and heterozygous null mutant embryos were carried
out and the data analysed by t-test to identify reproducible
differences in expression between those two genotypes. (B) Examples of the
expression in the Fgfr1 mutant cortex of genes normally expressed
caudally (green) and rostrally (red) in the E13 neocortex. Caudal genes are
upregulated, whereas rostral genes are downregulated in the Fgfr1
E12.5 mutant cortex. Average log base 2 (mean from nine independent
hybridisations) gene expression values are shown. Gene names are as indicated:
Osr1, odd-skipped related 1; Dct, dopachrome tautomerase.
(C) Neurogenic genes and genes expressed in differentiating neurons are
upregulated in the Fgfr1 mutant E12.5 neocortex. Genes shown include
a neurogenic gene expressed in progenitor cells (neurogenin 2), transcription
factor genes expressed in differentiating neurons (Neurod, Myt1l, Tbr1,
Tbr2, Lmo1) and genes expressed in differentiated neurons
(Epha3, alpha-synuclein, chromogranin B, Snap25).
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