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Fig. 5. Fate maps in Hh-deficient embryos. (A,C) PKH labeling immediately after
injection, lateral views. (B, D) Labeled cells at 80 hpf derived from these
injections, showing co-localization (yellow) of PKH (red) and
sox10:egfp (green) in dissected preparations, ventral views. (A) NC
cells labeled dorsal to the optic vesicle do not contribute to cartilage, but
remain undifferentiated (B, arrows). (C) By contrast, cells labeled posterior
to the optic vesicle contribute to the midline cartilage rod (D, arrowheads)
and posterior trabeculae (arrows). (E) Schematic representation of the fate
map in Hh-deficient embryos. Trabecular precursors form cartilage (blue),
whereas ethmoid progenitors (red) do not. Scale bars: 50µm; in A for A,C;
in B for B,D.
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