spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online August 25, 2005

Development 132, 1804e (2005)
© The Company of Biologists Limited
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

In this issue

Long live spermatogonial stem cells


Stem cells are believed to possess special machinery that allows them to replicate indefinitely without accumulating defects. However, embryonic stem and embryonic germ cells often acquire chromosomal and imprinting abnormalities in culture, making the findings of Kanatsu-Shinohara and colleagues (see p. 4155) somewhat surprising. These authors cultured spermatogonial stem cells, derived from newborn mouse testes, for two years and found them to be remarkably genetically and epigenetically stable over this time. The cells' stability is reflected in their ability to produce normal sperm when transplanted into infertile mice, and by the fact that this sperm can generate normal, fertile offspring when used in IVF experiments. The only detectable change, the authors report, is a shortening of the telomeres of the stem cells, but this occurs so slowly that it should not hamper the future use of these cells as a tool for genetic modification.


Related articles in Development:

Genetic and epigenetic properties of mouse male germline stem cells during long-term culture
Mito Kanatsu-Shinohara, Narumi Ogonuki, Tomohiko Iwano, Jiyoung Lee, Yasuhiro Kazuki, Kimiko Inoue, Hiromi Miki, Masanori Takehashi, Shinya Toyokuni, Yoichi Shinkai, Mitsuo Oshimura, Fumitoshi Ishino, Atsuo Ogura, and Takashi Shinohara
Development 2005 132: 4155-4163. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content