QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online August 25, 2005

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Heart valve development: from genes to cells

Heart valves form from endocardial cushions during late development to prevent retrograde blood flow. Because cardiac valve and heart septation defects are common human congenital disorders, it is crucially important to understand their aetiology. On p. 4193, Beis and colleagues shed light on heart valve formation through a combination of approaches in zebrafish. From their studies, they identify a new step in early valve formation that is characterised by changes in the shape and adhesion-marker profile of endocardial cells in the atrioventricular canal (AVC). These changes fail in sih mutants whose hearts do not contract, indicating that they depend on the heart's mechanical function. They also depend on Notch signalling, which the authors show restricts this differentiation program to the correct cells in the AVC. Further insights are likely to arise from the large-scale genetic screen also reported here, which provides a valuable resource for the further dissection of this clinically important developmental process.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development

Dimitris Beis, Thomas Bartman, Suk-Won Jin, Ian C. Scott, Leonard A. D'Amico, Elke A. Ober, Heather Verkade, Julie Frantsve, Holly A. Field, Ann Wehman, Herwig Baier, Alexandra Tallafuss, Laure Bally-Cuif, Jau-Nian Chen, Didier Y. R. Stainier, and Benno Jungblut
Development 2005 132: 4193-4204. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?