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Fig. 4. Modulation of the WNT pathway does not change mesoderm or neural plate
patterning. At head-fold stages, Wnt8c is expressed in the cranial
lateral plate mesoderm (A,A'; lp) next to the pre-placodal region (ppr;
bracket), in the trunk mesoderm (A,A''; mes) and the neural plate
posterior to the pre-placodal region (A,A''; np). Lines in A
indicate the positions of the sections shown in A' and A'',
respectively. (B,C) Misexpression of Crescent (brown in C) does not result in
expansion of the heart mesoderm marker Nkx2.5. (D-G) Misexpression of
activated ß-catenin (brown in E and G) does not alter the expression of
the regional neural markers Fgf3 (D,E) and Krox20 (F,G).
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