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First published online September 9, 2005

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Cut to the endocycle

The switch from a mitotic cell cycle to an endocycle (DNA replication without mitosis) that occurs in Drosophila oogenesis is an excellent system in which to study how developmental signals control the cell-cycle machinery. Sun and Deng now report that the downregulation of the homeodomain protein Cut by Notch contributes to the mitotic cycle/endocycle switch and to cell differentiation in Drosophila follicle cells (see p. 4299). Cut, they show, is expressed in proliferating follicle cells but not in endocycling cells. This downregulation of Cut expression is induced by Notch signaling. The researchers report that Cut promotes the expression of Cyclin A, the essential mitotic cyclin, by negatively regulating Fizzy-related, an anaphase-promoting complex/cyclosome adaptor. These and other results suggest that Cut functions as a linker between Notch and the genes that are involved in cell-cycle progression and cell differentiation.

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Related articles in Development:

Notch-dependent downregulation of the homeodomain gene cut is required for the mitotic cycle/endocycle switch and cell differentiation in Drosophila follicle cells

Jianjun Sun and Wu-Min Deng
Development 2005 132: 4299-4308. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?