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First published online September 9, 2005

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Enhanced long-distance communication

Enhancer-promoter communication is important for the expression of developmentally regulated genes. But how is this communication achieved when an enhancer lies far from its target promoter? Vanolst and co-workers now report that such long-range communication might be achieved through chromatin remodelling, at least during Drosophila neural development (see p. 4327). During this process, enhancer-promoter communication is facilitated by the formation of a multiprotein complex in which Pannier (Pnr), bound to a remote enhancer of the achaete-scute (ac-sc) complex, is linked to an (Ac-Sc)-Daughterless heterodimer that is bound to ac-sc promoters through the protein Chip. The researchers show that Toutatis, a protein containing domains found in chromatin remodelling proteins, and Iswi, a chromatin remodelling factor, positively regulate the activity of Pnr and Chip. Since the Brahma chromatin remodelling complex negatively regulates Pnr/Chip activity, these new results suggest that chromatin remodelling may be a general mechanism by which enhancer-promoter communication is facilitated during Drosophila neural development.

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Related articles in Development:

Toutatis, a TIP5-related protein, positively regulates Pannier function during Drosophila neural development

Luc Vanolst, Catherine Fromental-Ramain, and Philippe Ramain
Development 2005 132: 4327-4338. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?