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Fig. 2. Phenotypic defects in fibulin-1 (hd43) mutants. All panels except
for G and H are oriented with dorsal up and anterior to the left. (A,B) Gonad
migration in wild-type (A) and fbl-1(hd43) mutant (B) L4
hermaphrodites. Arrows indicate the position of the migrating distal tip cell;
arrowheads indicate the width of the proximal gonad. (C,D) Gonad migration in
wild-type (C) and fbl-1(hd43) mutant (D) L4 males. Arrows indicate
the position of the stationary distal tip cell; arrowheads indicate the
position of the seminal vesicle that is severed from the vas deferens and
retracted to a dorsal anterior position in mutant. (E,F) Pharyngeal morphology
in wild-type (E) and mutant (F) hermaphrodites. Arrows indicate the region of
constriction and asymmetry in metacorpus; arrowheads show the abnormal width
of the metacorpus and terminal bulb. (G,H) GFP-integrin ß pat-3
distribution in wild-type (G) and fbl-1(hd43) mutant (H) body-wall
muscle. Large arrow shows region of GFP-integrin ß pat-3 accumulation at
muscle-muscle junctions in wild-type animals only, and small arrows show the
gaps at muscle-muscle junctions in the fbl-1(hd43) mutant. (I,J)
Intestinal cells expand to fill posterior body cavity in wild-type (I) but not
fbl-1(hd43) mutant (J) animals. Arrows in I and J indicate the basal
surface of posterior intestinal cells. Scale bars: 10 µm.
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