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Fig. 4. Whole-mount in situ hybridization analysis of gene expression in Tcre;Fgfr1 E10.5 forelimb buds. The mesenchymal expression of Shh, gremlin (Grem), Bmp4, Hoxa13 and Hoxd13 is reduced in the mutant, while the mesenchymal expression of Alx4 and Bmp2 and the AER expression of Bmp4 and Bmp2 is increased in the mutant.





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