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Fig. 7. A schematic drawing showing how Notch might regulate cell-cycle transition and cell differentiation through Cut. In early oogenesis, Cut is expressed in all follicle cells and maintains the normal mitotic cycle partially by suppressing the APC/C adaptor, Fzr (Fizzy-related); it maintains the follicle cells in the undifferentiated cell fate. During the cell-cycle transition from the mitotic cycle to the endocycle, upregulated Dl (Delta) from germline cells binds to Notch receptor and activates Notch signaling in follicle cells. Activated notch signaling activates gene X and indirectly turns off Cut through X, which results in follicle-cell differentiation from the immature state to the mature state. At the same time, lack of Cut expression derepresses fzr. Activated notch signaling somehow downregulates Stg (String), a G2/M promoter, and prevents the follicle cell from going into M phase. A high level of Fzr can activate APC/C E3 ligase to degrade G2 cyclins and allow follicle cells in G2 phase to by-pass the M phase and get into G1 phase directly.

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