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Fig. 2. Micro-computed tomography of Gja1^Jrt/+ skulls. Surface renderings of average skulls in orthographic projection were constructed from five Gja1^Jrt/+ mice and five control mice (+/+) ranging in age from 54-60 weeks of age. There are differences seen in profiles along the dorsal surface of the skull. Average skull shapes were overlaid with the magnitude of the deformation needed to map the control skull (+/+) onto the average Gja1^Jrt/+ skull. The false color range (indicative of deformation) is from 120 µm (black) to 720 µm (white). Colored regions were statistically significant (P<0.01) by a Hotelling T² statistic comparing the two groups. There is a large deformation across the bridge of the nose depressing the nasal bone and eye sockets by 668±218 µm and 760±150 µm, respectively, as well as the outward displacement of the frontal bone and occipital bone of 680±265 µm and 460±269 µm, respectively.

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