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Fig. 8. Ptch1 expression in wild type and Sufu-/- mutants. Whole-mount in situ hybridization using a Ptch1 digoxigenin-labeled riboprobe on wild-type (A) and Sufu-/- (B) embryos at 9.5 dpc. The Sufu-/- embryo exhibited an expansion of the expression domain and gross overexpression of Ptch1.





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