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First published online December 28, 2004

Development 132, 201e (2005)
© The Company of Biologists Limited
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In this issue

Gut projections: the hedgehog connection

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During the development of the small intestine, a smooth-surfaced endodermal tube is remodelled to form finger-like projections (villi), where food absorption occurs, and flask-shaped invaginations (crypts), which contain the intestinal stem cells. On p. 279, Madison and colleagues report that a combined sonic (Shh) and Indian (Ihh) hedgehog signal produced by the epithelial cells in the developing intestine controls villus formation and patterning in a paracrine manner. By generating transgenic mice that express hedgehog (Hh) interacting protein – a pan-Hh inhibitor – in the neonatal intestine, the researchers show that even weak inhibition of Hh signalling perturbs crypt/villus patterning, causing the mislocalisation of subepithelial myofibroblasts to the villus tips and increased epithelial proliferation. Overall, conclude the researchers, the intestinal epithelium normally patterns the crypt-villus axis by sending Hh signals to underlying subepithelial myofibroblasts, the likely producers of the Wnt signals that control epithelial proliferation.


Related articles in Development:

Epithelial hedgehog signals pattern the intestinal crypt-villus axis
Blair B. Madison, Katherine Braunstein, Erlene Kuizon, Kathleen Portman, Xiaotan T. Qiao, and Deborah L. Gumucio
Development 2005 132: 279-289. [Abstract] [Full Text]  




This Article
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