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First published online December 28, 2004

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Neural induction controversy resolved?

How neural induction is achieved in vertebrates is hotly debated. The default model of neural induction, which is based on experiments in frog ectodermal explants, proposes that inhibition of bone morphogenetic protein (BMP) signalling specifies neural fate. In chick and zebrafish embryos, however, neural induction is initiated by fibroblast growth factor (FGF) signalling. Delaune and colleagues now report that neural induction in whole frog embryos requires both FGF signalling and BMP inhibition (see p. 299). By using BMP and FGF signalling inhibitors, the researchers show that pre-gastrula ectodermal FGF signalling is required for neural induction in frogs. They propose that, in addition to inhibiting BMP, FGF signalling directly drives neural induction. However, definitive proof of a BMP-independent role for FGF signalling in frog neural induction awaits the identification of a transcriptional target that acts in a pathway that is essentially required for neural specification.

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Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition

Emilie Delaune, Patrick Lemaire, and Laurent Kodjabachian
Development 2005 132: 299-310. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?