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Fig. 2. Autonomy of esrom gene function. (A) Transplantation of a wild-type eye into a mutant host. Axons from the anterior region of the wild-type eye (red) remain fasciculated and project to the posterior tectum. Axons from the host eye (green) branch aberrantly and are not tightly fasciculated in the optic tract. (B) Transplantation of a mutant eye into a wild-type host. Axons from the anterior region of the host eye (green) project to the posterior tectum, whereas those from the mutant eye (red) terminate in the anterior tectum. AF7 is indicated by the arrowhead. (C) Wild-type retinal axons fasciculate in vitro. (D) Mutant axons do not fasciculate as strongly. Scale bar: 50 µm. Anterior is towards the left.





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