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Fig. 8. Proposed model for the involvement of GL3/EGL3 in a novel intercellular
regulatory circuit. A WER/GL3/EGL3/TTG complex forms in cells in the N
position and promotes expression of GL2 and CPC.
Accumulation of GL2 in the N-position leads to the specification of the
non-hair cell fate, while CPC/(TRY) moves laterally to the neighboring cell in
the H position to form the inactive complex CPC/GL3/EGL3/TTG, which prevents
expression of GL2 in the future hair cell. The presence of CPC/(TRY)
in the H position also leads to activation of GL3 and EGL3
expression. In a lateral feedback loop, GL3/(EGL3) protein moves to the N cell
to participate in the WER/GL3/EGL3/TTG complex, which activates GL2
and CPC and inhibits expression of GL3 and EGL3.
See text for further discussion. Unbroken lines indicate gene transcription
regulation; broken lines indicate protein movement; dotted lines indicate
little/no transcription regulation. Proteins shown in white are at a low
concentration.
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