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Fig. 2. Npn1 mediates Sema3a signaling in dental axons. Frontal sections of E13.5 trigeminal ganglia (A,B) and tooth germs (C,D). Bright- (A1,B1) and dark-field (A2,B2) images. (A1-B2) A prominent Npn1 expression is seen in the trigeminal ganglion, while no specific expression of Npn2 is observed. (C) Npn1 immunoreactivity is seen in the dental nerve fibers (arrows) next to the condensed dental mesenchyme (dm) and in the trigeminal superior alveolar nerve trunk (sn). (D) E12.5 Npn1-/- heads analyzed by peripherin antibodies show that ectopic nerve fibers are prematurely present next to the dental epithelium and in the area of the condensing dental mesenchyme (arrows). Trigeminal inferior (in) and superior alveolar nerve trunks are abnormally defasciculated. Scale bars: 100 µm.





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