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Fig. 2. Forebrain abnormalities and megalin expression pattern in E14.5 embryos with conditional megalin gene inactivation. (A-D) Immunohistological detection of megalin in yolk sac (A,B) and neuroepithelium (C,D) of E14.5 embryos. megalin^lox/lox embryos express the receptor in the yolk sac (A) and the neuroepithelium (C), whereas megalin^lox/lox/Meox2^tm1(cre)Sor embryos express the receptor in the yolk sac (B) but not in the neuroepithelium (D). (E,F) Exencephalus in E14.5 embryos with ubiquitous (megalin^–/–) (E) or with epiblast-specific (megalin^lox/lox/Meox2^tm1(cre)Sor) megalin gene knockout (F).

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