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First published online September 28, 2005

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Placing an asymmetric spindle

Asymmetric cell divisions, which help to generate cell diversity during development, often involve eccentric positioning of the mitotic spindle. On p. 4449, Afshar and colleagues report that the G proteins GOA-1 and GPA-16 activate the same spindle positioning pathway in one-cell C. elegans embryos but are regulated differently. The researchers show, for example, that both proteins localize to the cortex of the one-cell embryo, and that both bind RIC-8 and GPR-1/2 – all four proteins help to generate the pulling force needed to position the mitotic spindle. However, whereas GPR-1/2 acts as a guanine nucleotide-dissociation inhibitor for both GPA-1 and GOA-1, RIC-8 is a guanine nucleotide-exchange factor for GOA-1 only. Conversely, RIC-8 is required for the cortical localization of GPA-16 but not GOA-1. These and other observations provide new insights into the mechanisms of asymmetric spindle positioning.

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Related articles in Development:

Cortical localization of the G protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division

Katayoun Afshar, Francis S. Willard, Kelly Colombo, David P. Siderovski, and Pierre Gönczy
Development 2005 132: 4449-4459. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?