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Fig. 8. Growing wild-type cells secrete a 
150 kDa factor that represses cell
proliferation, and aprA- cells do not accumulate this
factor. Conditioned growth media from the indicated cell types were
fractionated on the Superose gel filtration column used for
Fig. 1. Indicated fractions (5
µl), as well as 5 µl of the column buffer (Buffer) were added to
wild-type cells, and the cells were counted 24 hours later. Values are
means±s.e.m. from three independent assays. The difference between the
counts for fraction 29 of the exudates from wild type and
aprA- is significant (P<0.025;
t-test).
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