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Fig. 4. Semithin transverse sections (dorsal, top) at the axial level of the
adrenal gland of an E17.5 wild-type embryo (A) and an
SF–/– littermate (B), showing the position of the right
adrenal gland, the suprarenal ganglion, the upper pole of the kidney, the
liver and the crus dextrum of the diaphragm. Electron micrographs have been
made on tissues corresponding to the demarcated areas: red (C,D) and black
(E,F). Cells with the typical ultrastructural features of chromaffin
progenitor cells, which contain large dense core vesicles (arrowheads), are
present in wild-type (C) and knockout (D) embryos in the areas that have been
demarcated with red dashed lines (A,B). Electron micrographs (E,F) from the
areas demarcated with black dashed lines (A,B) show typical sympathetic
neurons of the suprarenal ganglion, which appear identical in wild-type (E)
and Sf1–/– (F) embryos. Scale bars: 100 µm
in A,B; and 2 µm in C-F. ag, adrenal gland; cp, chromaffin progenitor
cells; d, crus dextrum of the diaphragm; k, upper pole of kidney; lv, liver;
srg, suprarenal ganglion.
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