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Fig. 3. sdn-1 mutants show midline crossover defects of VNC interneurons. (A) Schematic of PVQL/R interneurons. (B) PVQL/R interneurons run parallel to the head in the wild type. (C) PVQ axons inappropriately cross the midline in sdn-1 mutants, leading to collapsed axon tracks (arrowheads). (D) Schematic of the AVKL/R interneurons. (E) Wild-type AVKL/R run next to each other, whereas midline crossing of AVKL/R axons can be observed in sdn-1(zh20) worms (arrowheads) (F). (G) Schematic of HSNL/R motoneurons. (H) HSNL/R stay ipsilateral in the wild type, whereas HSNL/R axons frequently cross to the contralateral side in sdn-1(zh20) null mutants (arrowheads) (I). All schematics and photos are ventral views, anterior is to the left. N, number of animals scored. Scale bars: 10 µm.





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