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Fig. 7. Model for syndecan function in axon guidance signaling. Syndecan (SDN-1) on
the neural growth cone exposes HS chains with `neuron-specific' sugar
modifications, here simplified by 6Osulfations. The HS side chains of
syndecan bind specific guidance cues (e.g. SLT-1) and modulate signaling by
cognate high-affinity receptors, such as the SAX-3/Robo receptor (co-receptor
function). Genetic analysis suggests that parallel signaling to syndecan
relies on distinct sugar motifs on additional HSPGs in a context-dependent
manner. In PVQ interneurons, this parallel pathway involves HS with
epimerization (green), whereas in motoneuron development it involves both
epimerization and 6O-sulfation. The HS modification patterns may thus
define the specificity of different ligand/receptor interactions; A and B
represent different ligands.
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