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Fig. 2. Pancreas-specific ß-catenin knockout (PBKO) mice. (A) Breeding scheme to generate wild-type (green) and PBKO (red) genotypes. (B,C) Gross appearance of neonatal wild-type and PBKO guts. (D,E) Dorsal (red) and ventral (blue) pancreata highlighted in above genotypes. (F,G) Hematoxylin and Eosin stained sections of wild-type and PBKO pancreata reveals the abnormal morphology of latter genotype, and the scarcity of acini (arrowheads). (H-K) Immunostaining (brown) for insulin (H,I) and glucagon (J,K) in wild-type and PBKO pancreata reveals large clumps of islet tissue in the latter genotype; Hematoxylin counterstain is blue.





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