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Fig. 5. Relative impact of ß-catenin deletion on the endocrine and exocrine compartments. In situ hybridization (purple) to detect insulin1 (A,A'), proglucagon (B,B') and carboxypeptidaseA1 (Cpa1) (C,C') on near-adjacent sections of E15.5 wild-type (A-C) or PBKO (A'-C') pancreata. (D) Morphometric quantitation of in situ hybridization to calculate endocrine and exocrine volumes in wild-type (n=3) and PBKO (Catnb{Delta}/lox;Pdx1-Cre; n=4) pancreata. Shown are individual measurements (points) and means (bars); the difference between wild type (green) and PBKO (red) is statistically significant only for Cpa1 (P<0.05 by two-tailed t-test).





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