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Fig. 8. ß-catenin is dispensable for maintenance and function of adult endocrine cells. Confocal immunofluorescence reveals that nearly all insulin+ islet cells are ß-catenin-deficient in PBKO adult pancreata (A,A'), whereas all amylase+ acinar cells retain ß-catenin expression (B,B'), just as in the developing organ. (C) Glucose tolerance tests of wild-type (n=5) and PBKO (n=5) adult mice. Points represent mean blood glucose for each timepoint following intraperitoneal glucose injection (2 mg/g body weight), error bars indicate standard deviation. There are no statistically significant differences between genotypes at any timepoint. is, islet.





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