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Fig. 5. Involution-associated gene expression patterns are significantly altered in
the absence of C/EBP
. (A) Multiprobe ribonuclease protection assay of
the indicated genes in total RNA from mammary glands of two mice per genotype
and time point. Connecting lines were drawn as a visual aid. Shaded boxes
indicate the time points of most significant differences between wild-type and
C/EBP null glands. (B) Northern analysis of the indicated genes in
total RNA from mammary glands during lactation (Inv d0) and 1-4 days after
removal of the pups (two mice per group). (C) A selection of the data from
panel B quantified by phosphoimaging and normalized to cyclophilin (CK18) or
CK18 (IGFBP5, SGP2, p53) expression. (D) Northern analysis of the indicated
genes in total RNA from mammary glands on days 0 and 1 of involution. Data
shown are the phosphoimage quantifications of expression levels in four to
five mice per data point normalized to cyclophilin expression. a.u., arbitrary
units.
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