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Fig. 4. Reelin-blocking antibody alters the direction of migration of basal forebrain neurons. (A,C) Drawings of sagittal sections through E18 rat brains showing placements of fluorescent CMTMR particles at the junction of the olfactory bulb region and the basal forebrain as well as the migratory routes (red dotted lines) taken by labelled cells in control (A) and CR-50-treated slices (C). Vertical lines separate the parts of the sections rostral to the dye placement from those located caudally. (B,D) Streams of labelled cells moving away from the site of CMTMR placement. Note that in the treated slice, a mass of fluorescent cells is directed rostrally. (E) Counts of labelled cells in control and CR-50-treated slices indicated that in the former, cells moved caudal to CMTMR placement but, in the latter, cells took a rostral course (n=12 slices for each case; ***P<0.001; Student's t-test). OB, olfactory bulb; Cx, cerebral cortex; Th, thalamus; BF, basal forebrain; H, hypothalamus. Scale bar: 500 µm.





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