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Fig. 6. Reduction in number and aberrant position of GnRH neurons in E18
reeler mice. (A) Cell counts revealed a significant reduction in the
total number of GnRH neurons in the brains of reeler mice
(reeler, 417.0±31.75; wt, 748.0±4.04; n=3 for
each genotype; *P<0.05; Student's t-test), but a relative
increase in the number of these cells in the cortex compared to wild type (wt)
animals (reeler 41.11±9.77; wt, 9.793±3.97;
*P<0.05; Student's t-test). (B) Drawing of a sagittal
section depicting the areas (boxes) selected for analysis. (C-H) Images of
immunohistochemically stained GnRH neurons in OB, BF and Cx of wild-type and
reeler brains. Streams of neurons entering the brain (asterisk in C
and D) are directed towards the basal forebrain (large arrows in C and D
indicate direction of stream) in both groups of animals, but reeler
show an additional stream directed towards the cortex (small arrow in D). Note
the overall reduction in GnRH neurons in the BF of reeler mice
(arrowheads in F) and the increase of these neurons in the cortex (arrowheads
in H). OB, junction of olfactory bulb and forebrain; BF, basal forebrain; H,
hypothalamus; Cx, cortex. Scale bar: 50 µm.
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